Jesus and Mo is one of my favorite web comics. It features the everyday adventures of Jesus (as in, Christ), and Mohammed (as in, the Prophet). The comic makes the neat concession that both Jesus and Mohammed are real, and they have an apartment together.
You should know before you read Jesus and Mo that it’s definitely not the sort of comic that worries about whose toes it’s stepping on. There are very strong religious themes, obviously, and my favorite part about the comic is the constant interplay between the two main characters and a Barmaid who we never see, but who is an atheist. Some of the philosophical discussions Jesus and Mo have with her are highly entertaining; despite seeing evidence before her eyes that both of the main characters really do exist, she persists in not believing in any sort of higher power.
Readers going to the site expecting the artistic polish of web comics such as Penny Arcade are sure to be disappointed; however, it’s Jesus and Mo‘s humor that really shines, much like XKCD (if slightly less full of stick figures). The comic occasionally gets a little over the top, but it’s enjoyable nonetheless.