…According to Wizard, at least. Millar explains the story:
…“Enemy of the State” was “Wolverine versus the Marvel Universe.” Just on a primal level as a fanboy, that appeals to me. This is entirely different. In this, the Marvel Universe as we understand it is gone. The superheroes are gone. There’s a few scattered guys left around, and they’re living in the remains of the Marvel Universe. Some terrible incident happens. America is absolutely f—ed. There’s nothing left but a wasteland really. It’s more like “Mad Max” than the Marvel Universe, but amongst that we see its remains. We still have some of the supervillains, but what they’ve done now is had children and grandchildren in some cases. So we’ve got gangs out in the states now. And there are ecological problems because we’re 50 years in the future by this point. It’s unlike any Marvel story you’ve ever had before. It’s more like a European thing. It’s just this horrible post-apocalyptic nightmare that happens to have superheroes and supervillains in it, and Wolverine is at the heart of it.
That sound you hear is probably the cash registers ringing in advance.